Cytotoxic Activity of Volatile Compounds in Cymbopogon nardus’ Essential Oils

Abstract: Plants produce a variety of secondary metabolites, one which is essential oils that contain volatile compounds and are useful for humans. Cymbopogon nardus contains can inhibit the proliferation cancer cells. This research aims to explore antiproliferation activity C.nardus’ with different concentrations against breast Michigan Cancer Foundation-7 (MCF-7) Antiproliferation test was carried out total cells method using trypan blue were calculated microscope. Gas Chromatography-Mass Spectrometer (GC-MS) performed identify compounds. The results showed Inhibitory Concentration 50 (IC50) value 359.6 ppm an inhibition percent 44.49% at 170 ppm. Meanwhile, Vero normal cell 29.04%, compared Doxorubicin 35.23%. dominant compound in C. nardus’ oil Geraniol Citronellol.Abstrak Tanaman menghasilkan berbagai macam metabolit sekunder, salah satunya dalam bentuk minyak atsiri yang mengandung senyawa volatil berguna bagi manusia. dapat menghambat proliferasi sel kanker. Penelitian ini bertujuan untuk mengetahui aktifitas antiproliferasi dengan beberapa konsentrasi terhadap kanker payudara State (MCF-7). Uji dilakukan metode menggunakan dan dihitung mikroskop. mengidentifikasi volatil. Hasil menunjukkan bahwa penghambatan sebesar persen pada Sementara itu, ihibisi dibandingkan Doksorubisin Senyawa dominan terdapat adalah Citronellol.